Vivarium Services

TrueBinding Vivarium is a leading provider of comprehensive services for animal research and experimentation. We offer expertise in IACUC protocols, animal ordering, housing, and high standards of care. With round-the-clock animal health surveillance, we ensure the well-being of our animals. Our facility provides complete veterinarian oversight, including treatment, care, and specialized procedures such as animal dosing and blood sampling.

Equipped with advanced imaging capabilities, including MRI/PET, bioluminescence, and fluorescence imaging, we support cutting-edge research. Our expertise extends to lung function measurements, rodent ultrasound, and blood pressure monitoring. We possess the RS-2000 Biological System for precise irradiation, and our surgical capabilities include basic and invasive procedures like stereotaxic surgeries and injections.

TrueBinding Vivarium excels in human disease animal modeling, PK/PD studies, safety and toxicology evaluations, as well as mice breeding. We offer comprehensive services such as animal disease scoring, metabolic cage studies, and behavioral experiments using various equipment. With a commitment to client success, we provide training for all our activities. Our mission is to facilitate scientific research by providing top-notch services, expertise, and state-of-the-art equipment.

Testing

  • Von Frey- testing analgesia, nociception, neuro-pathologies and post-operative pain (BIO-EVF4-S and elevated metal mesh stand, BIOSEB)

  • OCT SPECTRALIS for ophthalmic imaging (HEIDELBERG ENGINEERING)

  • Controlled Cortical Impactor (for Traumatic Brain Injury modeling)

  • Spinal Cord Injury Impactor

  • Blood Pressure (CODA Non-Invasive Blood Pressure System, Kent Scientific CORP.)

  • Pressure Volume Millar Catheters (AD Instruments)

  • Stereotaxic instruments for surgery (Stoelting)

  • Glucometers for Glucose test; GTT/ITT (Glucose201, HEMOCUE)

  • Behavior-Rotarod test (MAZE Engineers)

  • Water maze and Barnes Maze

  • MPVS Ultra Foundation Systems, transonic for cardiovascular (AD Instruments)

Basic Animal Care

  • High Standards of Basic as well as Specialized Animal Care

  • Round the Clock Animal Health Surveillance Program

  • Complete Veterinarian Oversight, treatment and care

Administrative

  • Help with IACUC Protocols, Drafting, Renewals and Amendments

  • Animal Ordering, Receiving and Housing

Animal Disease Modeling

Oncology: Liver Cancer, Pancreatic Cancer, Breast Cancer, Thyroid Cancer, Brain Cancer

Neurodegenerative Diseases: Alzheimer’s Disease, Stroke, Parkinson Disease, ALS, Huntington’s Disease, Spinal Cord Injury, Traumatic Brain Injury, Aging Studies, Multiple Sclerosis (EAE)

Inflammatory Diseases: Ashma, Lung Fibrosis, COPD, RACIA, Prostatitis, Sepsis, Glomerulonephritis, Inflammatory Bowel Disease, Rheumatoid Arthritis, Cystic Fibrosis

Autoimmune Diseases: Psoriasis, Lupus

Metabolic Diseases: Diabetes, Hypertension

Kidney Diseases: Kidney Fibrosis, Chronic Kidney Disease, Polycystic Kidney Disease

Liver Pathologies: NASH, HCC

Cardiovascular Diseases: Atherosclerosis, Heart Fibrosis, Heart Failure, Congestive Heart Failure, Deep Vein Thrombosis

Equipment

Capabilities

Mouse Study Designs

  • Non-GLP preclinical safety tox

  • Efficacy

  • PK/PD studies in Mice and Rats

  • Behavioral Study

  • Surgery

  • Target Validation

Mouse Services

  • Animal Dosing via all routes

  • Animal Blood Sampling via all routes

  • Humane Euthanasia and Complete Necropsy

  • Mice Breeding Services

  • Mouse CSF harvest (before perfusion)

Imaging

  • MRI/PET (NanoScan PET/MRI 3T, Mediso)

  • Ultrasound (Vevo3100, Vevo LAZR-X, VISUALSONICS)

  • Irradiation (RS-2000 Biological System, RAD SOURCE TECH.)

  • IVIS SPECTUM CT(PerkinElmer)

  • EchoMRI Body composition analyzer (EchoMRI)

  • 15 min to cGMP Facility

  • 15 min to SFO

  • 30 min to Oakland Airport

  • 30 min to Downtown San Francisco

Vivarium Services are located in Foster City, CA

Facilities

  • Innovive IVC Racks (Individual Ventilated Caging Systems) for Mice and Rats

  • Mouse/Rat metabolic cages

  • Biosafety and Fume Hoods

  • Dissection Microscopes

  • Surgery equipment and accessories

  • Radio Isotope Use station with lead shields and pits

Specialized Mouse Techniques

• MRI/PET for Mice and Rats (including Isotope ordering, receiving, use and disposal)

• Bioluminescence and Fluorescence Imaging

• Lung Function Measurements in Pulmonary Disease

• Rodent Ultrasound

• Blood Pressure Measurements for Mice and Rats

• Using RS 2000 Irradiator, Irradiation of rodents and cells

• Basic as well as Invasive Surgeries including Stereotaxic Surgeries and Injections

• Human Disease Animal Modeling and Optimization

• Animal Disease Scoring and measurements (e.g Tumors in oncology, foot and paws in arthritis etc.)

• Metabolic Cages studies in mice and rats

• GTT/ITT tests in rats and mice

• Behavioral experiments including use of Rotarods, Water Maze, Dry Maze etc.

 

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